![]() ![]() Li HL, Gu XH, Li BJ, Chen CH, Lin HR, Xia JH (2017a) Genome-wide QTL analysis identified significant associations between hypoxia tolerance and mutations in the GPR132 and ABCG4 genes in Nile tilapia. Kumar S, Tamura K, Jakobsen IB, Nei M (2001) MEGA2: molecular evolutionary genetics analysis software. Jerry DR (2013) Biology and culture of Asian seabass Lates calcarifer. Gerken T, Girard CA, Tung YCL, Webby CJ, Saudek V, Hewitson KS, Yeo GSH, Mcdonough MA et al (2007) The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Geng X, Liu SK, Yuan ZH, Jiang YL, Zhi DG, Liu ZJ (2017) A genome-wide association study reveals that genes with functions for bone development are associated with body conformation in catfish. Gan W, Song Q, Zhang N, Xiong X, Wang D, Li L (2015) Association between FTO polymorphism in exon 3 with carcass and meat quality traits in crossbred ducks. Nat Commun 4:1798įu Y, Li L, Ren S (2013b) Effect of FTO expression and polymorphism on fat deposition in Suzhong pigs. Endocrinology 149:2062–2071įu Y, Jia G, Pang X, Wang RN, Wang X, Li CJ, Smemo S, Dai Q et al (2013a) FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA. Science 316:889–894įredriksson R, HäGglund M, Olszewski PK, Stephansson O, Jacobsson JA, Olszewska AM, Levine AS, Lindblom J et al (2008) The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Nature 458:894–898įrayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JRB, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJF, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CNA, Doney ASF, Morris AD, Smith GD, The Wellcome Trust Case Control Consortium, Hattersley AT, McCarthy MI (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Meat Sci 84:645–650įischer J, Koch L, Emmerling C, Vierkotten J, Peters T, Brüning JC, Rüther U (2009) Inactivation of the Fto gene protects from obesity. ![]() Anim Biotechnol 20:58–70įan B, Lkhagvadorj S, Cai W, Young J, Smith R, Dekkers J, Huff-Lonergan E, Lonergan S et al (2010) Identification of genetic markers associated with residual feed intake and meat quality traits in the pig. Obesity 17:323–329įan B, Du Z-Q, Rothschild MF (2009) The fat mass and obesity-associated (FTO) gene is associated with intramuscular fat content and growth rate in the pig. Anim Genet 46:468–469ĭu ZQ, Fan B, Zhao X, Amoako R, Rothschild MF (2009) Association analyses between type 2 diabetes genes and obesity traits in pigs. Nat Genet 42:1086–U147ĭomingos JA, Zenger KR, Jerry DR (2015) Whole genome shotgun sequence assembly enables rapid gene characterization in the tropical fish barramundi, Lates calcarifer. Altogether, our data suggest that the gene or/and its linked genes play an important role in growth and fatty acid synthesis, and that the SNPs associated with traits may be used as markers for selecting quicker growth and higher omega-3/-6 ratio at the fingerling stage.Ĭheung M-KM, Yeo GS (2011) FTO biology and obesity: why do a billion of us weigh 3 kg more? Front Endocrinol 2:4Ĭhurch C, Moir L, Mcmurray F, Girard C, Banks GT, Teboul L, Wells S, Bruning JC et al (2010) Overexpression of Fto leads to increased food intake and results in obesity. growth, oil content, omega-3 and -6 contents) in an F 2 family demonstrated that the two SNPs were significantly associated with growth, oil content, omega-3 content and omega-3/-6 ratio. Analysis of associations between SNPs and traits (i.e. Comparative analysis of the genomic sequences of part of intron 1 of the gene among 10 unrelated individuals identified two SNPs. Analysis of its expressions using qRT-PCR showed that it was expressed ubiquitously, but was higher in the liver, stomach and intestine. Phylogenetic analysis revealed that the gene in Asian seabass was closely related to those of Japanese flounder and Nile tilapia. The gene consisted of nine exons and eight introns and was 117,679 bp in length. The full-length cDNA of the gene is 3679 bp, containing an ORF of 1935 bp encoding 644 amino acids, a 216 bp 5′ UTR and a 1538 bp 3′ UTR. ![]() We cloned and characterized the FTO gene in an economically important food fish species: Asian seabass ( Lates calcarifer). Little information of whether FTO plays an important role in aquaculture fish species is available. Polymorphisms in the FTO gene are associated with obesity and body mass index in humans and livestock. ![]()
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